This suggests that the C-terminal extension in RanGDP is crucial for shielding residues in the core domain and preventing the switch regions from adopting a GTP-like form. This prevents binding of transport factors to RanGDP that would otherwise lead to uncoordinated interaction between importin beta-like proteins and cellular factors.
Importin beta is a mitotic target of the small GTPase Ran in spindle assembly.
By sequence By domain architecture. Add your annotation Add your annotation.
P-loop containing nucleoside triphosphate hydrolase IPR Nature The ras protein family: Biochemistry 30 Refined crystal structure of the triphosphate conformation of H-ras p21 at 1. Structure of small G proteins and their regulators.
The small nuclear GTPase Ran: Intracellular signaling peptides and proteins. G protein-coupled receptor kinase AMP-activated protein kinase. Cyclin-dependent kinase inhibitor protein Cyclin-dependent kinase Cyclin. Phosphoinositide phospholipase C Phospholipase C.
Receptor-like protein tyrosine phosphatase Sh2 domain-containing protein tyrosine phosphatase. Pyrophosphatase Inorganic Thiamine Apyrase Thiamine-triphosphatase. Dynein Kinesin Myosin Katanin.
Rho family of GTPases: Its structure and its interaction with chromosome maintenance region 1 Crm-1 ". Pyrophosphatase Inorganic Thiamine Apyrase Thiamine-triphosphatase.
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- The small GTPase Ran: interpreting the signs - ScienceDirect?
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- Small GTPase?
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Dynein Kinesin Myosin Katanin. Rho family of GTPases: Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator. EC number Enzyme superfamily Enzyme family List of enzymes.
Small GTPase - Wikipedia